Mounting pressure to expand STEM capacity and improve recruitment is increasingly at odds with academic science buildings reaching the end of service life, and new renovation and reuse solutions are being forged for the challenge. Here, session leaders demonstrate three alternatives for renovation, expansion, and reuse of outdated facilities to expand capacity, implement modern pedagogies, and improve the scientific workspace. Through case studies from Purdue University, Ohio University, and Northwestern University, they identify reuse alternatives that meet program goals, reduce costs, and create modern spaces for student and faculty gathering, instruction, and collaboration.